Metabolic Engineering of Clostridium Tyrobutyricum for Butanol Production

A new strain of bacteria that can produce butanol at a high titer for transportation fuel.

Methods and Processes for Producing Butyrate Esters from Sugars

A method and process for producing butyrate esters for use as novel biofuels.These products have a similar energy content to biobutanol, but are easier to produce.

Combination Agent Approach for Improved Expansion and Mobilization of Hematopoietic Stem Cells

Combined treatment of plerixafor and Flt3L better mobilize stem cells and do not exacerbate graft-versus-host disease following transplatation.

Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis

Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.

Autophagosome-Lysosome Fusion Inhibition Enhances Flavopiridol Efficacy in Cancer

A novel method to increase the effectiveness and practicality of the cancer treatment drug Flavopiridol.

Methods for Making Three Dimensional Microfluidic Bioreactor Array

Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.

A Closed Loop System for Responsive Precise Intraparenchymal Delivery of Adenosine for the Treatment of Epilepsy

Medical device for controlling seizures.

Novel Small-Molecule Integrin-linked Kinase/Phosphoinositide-dependent Protein Kinase-2 Inhibitors

A novel set of molecules that inhibit integrin-linked kinase in order to suppress tumor cell growth and metastasis.

Discovery of a novel CD34(+) natural killer precursor population in human lymph nodes

Ohio State University researchers have discovered novel subset of human CD34 (+) hematopoietic precursor cells and generated a method of isolating them.

Family HealthLink: A Health Risk Assessment Tool

An online interactive tool that helps a patients and physicians assess a likelihood of cancer or heart disease, based on family history.

Development of a microRNA signature predicting local recurrence and overall survival after surgical resection for patients with pancreatic adenocarcinoma.

A molecular tool for predicting risk of local and regional recurrence of pancreatic adenocarcinoma.

Development of novel furano-parthenolides for human leukemia treatment

Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments.

Automating the quantification of color space parameters from Visible Spectrum Absorbance

Verbal communication of color is challenging, therefore mathematically-standardized color spaces are used. ColorBySpectra is software that in one click can convert large sets of absorbance data obtained from a simple spectrophotometer into color spaces: Hunter Lab, CIEL*c*h* and CIEL*a*b*. It reduces time for data collection, and sample volume and equipment needs. The software is useable on multiple platforms and would be useful in food science or other industries interested in precise color information.

Translational Activators of Glial Glutamate Transporter EAAT2

The Need

The most abundant neurotransmitter in the central nervous system is glutamate. The role of this neurotransmitter is to send excitiatory signals to aid in modulation of normal brain function. However, abnormal release of glutamate can overstimulate the neuronal system, resulting in excitoxicty. Glutamate-mediated excitoxicity is involved in many neurological disorders, such as epilepsy, stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). Currently available drugs for the prevention of excitoxicity are not very effective and can produce detrimental side effects. The interplay between glutamate release and clearance is controlled, in large part, by the glial glutamate transporter, EAAT2. Thus, drugs that are able to control the activation of EAAT2 provide a novel and promising direction for development of therapeutics for neurodegenerative diseases.

The Technology

The Ohio State University researchers, led by Dr. Chien-Liang Lin and in partnership with Brigham and Women's Hospital, have developed an approach for preventing glutamate-mediated excitotoxicity. This technology is a series of novel small molecules that enhance the glutamate uptake function through expression of an excitatory amino acid transporters, EAAT2, which causes the glutamate to be removed from the synaptic cleft. The way of enhancing the EAAT2 expression is through translational activation. These drugs provide a novel alternative to traditional therapeutics and hold promise for treatment of neurological diseases such as ALS.

Commercial Applications

  • Therapeutic drugs to treat neurodegenerative disorders


  • Enhances glutamate uptake function which allows glutamate to be removed from synaptic cleft

  • Therapeutic effect in several animal models of diseases including ALS, epilepsy, Alzheimer's disease, and focal cerebral ischemia

A novel synthetic immunomodulator and an adjuvant for vaccines

A natural plant product possessing potent immunomodulatory activity, which primes T cell immune responses, and could be used for vaccine development.

Targeting microRNAs for treatment of Cystic Fibrosis

Autophagy is impaired in patients with Cystic Fibrosis, rendering them susceptible to microbial infections. Autophagy is negatively regulated by microRNAs, Mir17 and Mir20, and this anti-microRNA antagomir may be optimized as a novel therapeutic to treat Cystic Fibrosis patients.

RNA Nanotubes for Single Molecule Sensing and DNA/RNA/Protein Sequencing

Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.

Cbl-b Inhibition as a Therapeutic Approach to Disseminated Candidiasis

A method to prevent disseminated candidiasis by targeting and inhibiting CBL-b, a ligase that prevents the immune system from functioning properly.

Pyrrolopyrimidine Derivatives as Mps1/TTK Kinase Inhibitors for Cancer Therapy

Small molecules for targeted treatment of triple negative breast cancer and other aggressive phenotypes.

A Novel Microbial Therapeutic to Diminish the Risk of Arteriosclerosis and Subsequent Heart Disease

Novel bacteria, specially formatted, could be utilized as a microbial therapeutic for diminishing the risk of arteriosclerosis and subsequent heart disease.