Antisense Morpholino Treatment to Increase SMN Levels and Treat Spinal Muscular Atrophy

A treatment for spinal muscular atrophy.



Antisense Oligonucleotide Development for Treatment of Spinal Muscular Atrophy

The SMN2 gene contains sequences that regulate the level of inclusion of SMN exon7 in SMN mRNA, and some of these act in a negative manner. Antisense oligonucleotides to block the negative regulating protein binding to these sites can increase inclusion of SMN exon 7 and thus, the amount of SMN being produced.



Method for treatment of diseases of central nervous system (CNS) and improvement of cognitive function by nanoscaffolds

A novel method to improve CNS metabolism and overall cognitive function as well as reduce peripheral neurodeneration, through the use of nanomatrices with or without identified redefined delivery biologicals and/or insulin.



Papverine Derivatives as Metabolic Radiosensitizers

Papverine derivatives that can be used as metabolic radiosensitizers. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papverine.



Gene delivery to adipose tissue using novel recombinant adeno-associated viral vectors

An engineered recombinant adeno-associated virus capable of targeting fat tissue previously inaccessible to this viral vector for the purposes of genetic manipulation.



A novel, third generation tissue factor-targeting immunoconjugate (L-ICON3) and its uses

Tissue factor targeting agent aimed at fighting pathologic angiogenesis.



DIAMOND

Data-Driven Inspection, Alerts, Maintenance, Observable Network Decision Control System with Cyber Action Taker to Address Less Inspected Hosts Including Cell Phones



Synthetic apratoxins and novel analogs for anticancer and therapeutic applications

Synthetic natural apratoxins and non-natural apratoxin analogs with improved pharmacokinetic profiles for cancer treatments and drug development applications.



Immunomodulating agents engineered from Notch receptor ligands: novel immunostimulatory anticancer agents and immunosuppressants

Immunomodulating agents have been engineered from Notch receptor ligand extracelluar domains. These are useful for stimulating the immune system.



MicroRNA Diagnostic Biomarkers and Therapeutic Targets for Pancreatic Cancer

A novel microRNA expression pattern for the detection and treatment of pancreatic cancer.



Simple tool for uniform excision and transfer of biological samples

A novel tool that offers improved efficiency, convenience, and precision for excision of DNA and protein bands or biological tissues.



Multifunctional RNA Nanoparticles and Methods for Treating Cancer

Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.



RadApp: A mobile application solution for centralized distribution of information to improve workflow, communication, networking, education, and patient safety in the healthcare setting.

The Need

Medical institutions depend on accessing many sources of changing information in various different forms to be successful. Moreover, distributing this information in a concise user-friendly way for each role in the department can be difficult. In particular, this is important for busy, tertiary-level academic departments and large private practices with physicians who are responsible for making critical medical decisions and diagnoses for complex patients across large systems. These physicians need to reach other healthcare providers to communicate critical findings, as well as contact staff providers to ensure appropriate testing is obtained and patient safety is considered. Integration of the trainee role including residents and fellows depending on the clinical setting is also paramount in order to continually support education and delivery of the best possible patient care. A mobile application that addresses all of these needs would prove essential for improving workflow efficiency and patient safety.

The Technology

The Ohio State University researchers Dr. Mina Makary and Nitin Egbert in the College of Medicine have developed RadApp, a mobile application for Android and iOS for centralized distribution of information to improve workflow, communication, networking, education, and patient safety in the healthcare setting. The application displays a centrally maintained list of resources with mobile-specific functionality for their use. This list includes hospital contacts that can be called and text paged; references, guidelines, staff schedules; access to a web-based evaluation/attendance recording system; and access to departmental and general radiology social media. Additional functions for ease-of-use include a rapid search tool and a "favorites" function for quick access to the most commonly used features of the app.

Commercial Applications

  • Departments looking to improve workflow efficiency and patient safety with a convenient, centralized source of information

    • Medical centers

    • Hospital Systems

    • Specialty Medical Practice Clinics

Benefits/Advantages

  • Menu options are populated from a centrally maintained list, allowing for customizability between different departments and hospital systems without administrators' need for programming knowledge
  • Resources accessible without an internet connection wherever possible
  • Resources have associated functionality accessible from within the application
  • Information easily searchable and be easily accessible
  • Maintenance does not require programming experience
  • Applicable to a wide-variety of operating systems including both Apple iOS and Android devices



Phyllanthusmin and acutissimalignan A compound derivatives for anticancer and immunostimulation

A group of potential antitumor arylnapthalene lactone derivatives, which may be developed as novel anticancer and immunostimulant agents.



Translational Activators of Glial Glutamate Transporter EAAT2

The Need

The most abundant neurotransmitter in the central nervous system is glutamate. The role of this neurotransmitter is to send excitiatory signals to aid in modulation of normal brain function. However, abnormal release of glutamate can overstimulate the neuronal system, resulting in excitoxicty. Glutamate-mediated excitoxicity is involved in many neurological disorders, such as epilepsy, stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). Currently available drugs for the prevention of excitoxicity are not very effective and can produce detrimental side effects. The interplay between glutamate release and clearance is controlled, in large part, by the glial glutamate transporter, EAAT2. Thus, drugs that are able to control the activation of EAAT2 provide a novel and promising direction for development of therapeutics for neurodegenerative diseases.

The Technology

The Ohio State University researchers, led by Dr. Chien-Liang Lin and in partnership with Brigham and Women's Hospital, have developed an approach for preventing glutamate-mediated excitotoxicity. This technology is a series of novel small molecules that enhance the glutamate uptake function through expression of an excitatory amino acid transporters, EAAT2, which causes the glutamate to be removed from the synaptic cleft. The way of enhancing the EAAT2 expression is through translational activation. These drugs provide a novel alternative to traditional therapeutics and hold promise for treatment of neurological diseases such as ALS.

Commercial Applications

  • Therapeutic drugs to treat neurodegenerative disorders

Benefits/Advantages

  • Enhances glutamate uptake function which allows glutamate to be removed from synaptic cleft

  • Therapeutic effect in several animal models of diseases including ALS, epilepsy, Alzheimer's disease, and focal cerebral ischemia



Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses

Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.



Selective Delipidation of Mycobacterium bovis BCG enhances its Vaccine Potential against TB

A novel method to increase vaccine effectiveness for TB



Intravenous (IV) Access Port Seal

A device to discourage IV-drug-abusing patients from self-accessing their IV ports while in the hospital



Small molecule growth inhibitors of avian pathogenic E. coli (APEC) as a means to control APEC infections in poultry.

Small Molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.



Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosis

Small Molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.