Compounds for treating solid tumors, non-solid tumors, leukemias and non-small cell lung cancer

The Need

Solid tumors are prevalent in almost all human cancers. Growth of solid tumors requires a supply of irregular-shaped blood vessels which causes tumors to be hypoxic in nature with low levels of oxygen. Currently, most treatments, involving radiation therapy and chemotherapy, have been found ineffective against solid tumors with hypoxic regions. Solid tumors are found throughout the body in the brain, lung, liver, and cental nervous system. Newer anti-cancer agents must be developed to attack such tumors and to prevent metastasis.

The Market

  • 23,380 adults in the U.S. will be diagnosed with cancerous tumors of the brain and spinal cord (American Society of Clinical Oncology)
  • 224,210 new cases of non-small cell lung cancers in the U.S. are expected to be diagnosed in 2014 (National Cancer Institute)
  • An estimated 33,190 new cases of liver cancer are expected to be diagnosed in 2014 (American Cancer Society)
  • Solid tumors account for more than 90% of all known human cancers (Ohio University)

The Technology

Dr. Platz has developed a novel water-soluble flavin N-oxide which can treat tumors, leukemias, non-small cell lung cancers and eradicate contaminants found in blood products.

  • Preferential elimination of chosen cancer cells over normal cells with flavin N-oxides has been established at a 5:1 ratio
  • Flavin N-oxides selectively attack the nucleic acids of hypoxic tumor cells while preserving the surrounding normal cells from being harmed
  • Effective dose of flavin N-oxides requires a concentration no greater than 100 micromolars

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