Adipose Derived Hormones for use in Topical Compounds

The Need

The skin care market is cluttered with a number of products that claim to have rejuvenating effects but provide little or no scientific explanation of how these effects are achieved. Compounds that rely on proven chemical agents such as tretinoin, while powerful, are often only available through a physician prescription and are limited by side effects such as photosensitivity and skin irritation. Protein, peptide and hormonal components such as adipose derived hormones (ADH) offer studied benefits, but the synthetic production of specific substances such as leptin is a cost-intensive process that merits investigating alternative methods for ADH generation.

The Market

  • Sales of topical cosmeceuticals amounted to nearly $33.4 billion in 2012, and are projected to increase to almost $42.8 billion in 2017, representing a CAGR of 5.1%
  • Appearance-enhancing products in the cosmeceutical segment are expected to increase from $14.8 billion in 2012 to $19.4 in 2017, representing a CAGR of 5.6%
  • Lipoplasty was the leading invasive procedure worldwide in 2011 with Abdominoplasty as the 4th most performed surgery. Together, these two fat removal procedures accounted for 29% of worldwide total aesthetic surgical procedures
  • A major factor driving growth in the skin care market is the high demand from the aging population for products that help maintain a healthy and youthful appearance. Furthermore, there is a large base of health-conscious and/or image-conscious consumers who are more than willing to spend significant sums on skin care products to maintain a youthful appearance

The Technology

The Ohio State University Researchers, Drs. Matthew During and Ergun Kocak, developed a topical skin care agent containing adipose-derived hormones (ADH), proven to rejuvenate skin. Adipose tissue was first recognized merely as a site of energy storage. However, increasing evidence indicates that adipose tissue secretes various bioactive molecules and exerts multiple functions in conjunction with the epidermis and dermis. Adipose tissue is now understood to play a role in the development and function of the skin. The positive impact of topical ADH suspended in a cream base was demonstrated on a candidate where the topical compound was applied selectively to some areas and not to others. Treated areas displayed improved appearance and smoother, fuller looking skin with fewer blemishes while untreated areas did not exhibit these characteristics.To address the expenses incurred by synthetic production of these biomolecules, ADH can be generated through an alternative pathway where individuals undergoing elective adipose tissue removal procedures may have their own tissues processed and refined into a personal, customized topical compound. Only small amounts of adipose tissue are required to make each portion of cream, therefore one removal procedure yields sufficient ADH-rich adipocyte lysate for many years of product use. Encapsulation and delivery mechanisms are analogous to those utilized to capture proteins from stem cell and other bioactive ingredients.

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