Technology Commercialization Office

Recently Published Techs:


Cbl-b Inhibition as a Therapeutic Approach to Disseminated Candidiasis

A method to prevent disseminated candidiasis by targeting and inhibiting CBL-b, a ligase that prevents the immune system from functioning properly.



Pyrrolopyrimidine Derivatives as Mps1/TTK Kinase Inhibitors for Cancer Therapy

Small molecules for targeted treatment of triple negative breast cancer and other aggressive phenotypes.



A Novel Microbial Therapeutic to Diminish the Risk of Arteriosclerosis and Subsequent Heart Disease

Novel bacteria, specially formatted, could be utilized as a microbial therapeutic for diminishing the risk of arteriosclerosis and subsequent heart disease.



SnapToQuery

A method for providing guidance and feedback during gesture-driven data exploration



Query Rewriting Infrastructure for Big Data Exploration

Middleware layer that queries in the context of sampling and improves efficiency of common statistical analyses.



Execution Framework for Highly Interactive Query Workloads

A database management systems that can execute joins with rapid response times.



Novel Anaerobic Microbial Process to Synthesize Ethylene

Methionine salvaging is a totally anaerobic (oxygen deficient) process by which large amounts of ethylene are made as a result of manipulating bacterial metabolism in select microorganisms.



Transformer: Rewriting Forms for Constrained Interaction

A program to transform time-consuming user-unfriendly electronic forms into user-friendly formats, saving up to 50% of user time.



ICARUS: Interactive Cleaning and Rule System

User friendly database validation software



Design and apparatus for efficient measurement of the time course of perceptual sensitivity change

A novel method of measuring the time course of degradation of perceptual sensitivity due to disease



Microalgal Based Animal Feed Supplements

A method of delivering chromium, copper, zinc, manganese, and selenium to cattle through transgenic algae.



Method for mass production of seleno-cysteine containing proteins from transgenic algae

Production of selenocysteine using transgenic algae to create industrial sized yields.



Thermogenic Biologicals Treatment of Obesity and Improvement of Insulin Resistance

Innovative thermogenic biologicals, methods of delivery, and combinational therapy for the treatment of abdominal obesity



Thermogenic Biologicals for Obesity Treatment

Identification and use of novel adipokines for reduction of visceral fat using thermogenesis.



Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures

A technique to increase the processing speed of data collection without losing accuracy



Iron Oxide Composites with Low Concentration of Aliovalent Dopants As Oxygen Carrier Materials for Sustainable Redox Combustion and Gasification Reactions in Chemical Looping Reactor Systems

Addition of low concentration aliovalent transition metal dopants substantially improves particle performance in chemical loopiong systems



Method for predicting statin response: combination of two CYP7A1 variants

A model to predict CYP7A1 activity and individual response to statins.



Use of 3D printing for personal optimized nasal drug delivery

The Need

Nasal sinusitis is one of the most common medical conditions in the US, affecting an estimated 12% of individuals, or some 29.4 million people (National Health Interview Survey 2015, CDC).Topical sinus irrigations (e.g. neti-pot, irrigation squeeze bottles) play an integral role in the management of sinusitis and are often more effective in drug delivery than other topical methods such as nasal sprays, nebulizers, or atomizers. However, due to the intricate anatomy of the human nasal airway, the ability to reach target sinuses is highly variable and unpredictable. While the irrigation procedure includes many variables, such as head position, injection angle, and flow rates, the optimal balance is unknown. Additionally, there are likely significant differences between individual sinuses that may change the optimal conditions. For this reason, when a patient's symptoms fail to improve after repeated irrigations, it is difficult to determine whether the irrigation itself is not working, or the irrigation doesn’t penetrate effectively.

The Technology

Researchers at The Ohio State University led by Kai Zhao, have developed an irrigation guidance method based on 3D printed replicas of patients' nasal cavities. These replicas provide patients and clincians with the ability to view models for determining more precise, personalized irrigation strategies.

Commercial Applications

  • Medicine
  • Personalized medicine
  • Models
  • Otolaryngology

Benefits/Advantages

  • Can be applied to nasal drops/ sprays
  • Visualization of the best technique for irrigation
  • More effective at-home treatment


Design and apparatus for quantification of the mapping of the sensory areas of the brain

A new tool that can quantify the sensory maps of the human brain. The tool can be used to quantify plasticity and pathology in the sensory areas of the human brain that are associated with normal and abnormal development, aging, and diseases in sensory systems. The first application of the tool, on retinotopic maps of the visual cortex, has generated excellent results.



Cellular Treatment of Metabolic Disorders

The implantation of engineered thermogenic cells for treating metabolic disease






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