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A novel anti-cancer agent (OSU-2S) that is devoid of S1P1 receptor activity and is highly effective in suppressing hepatocellular carcinoma tumor growth in vivo.
A completely pneumatic, multi-directional, bladeless, personal cooling device for hospital patients
An improved thin-film composite membrane which will efficiently purify greater amounts of water for reverse osmosis applications
A new strain of bacteria that can produce butanol at a high titer for transportation fuel.
A method and process for producing butyrate esters for use as novel biofuels.These products have a similar energy content to biobutanol, but are easier to produce.
Combined treatment of plerixafor and Flt3L better mobilize stem cells and do not exacerbate graft-versus-host disease following transplatation.
Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
A novel method to increase the effectiveness and practicality of the cancer treatment drug Flavopiridol.
Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Medical device for controlling seizures.
A novel set of molecules that inhibit integrin-linked kinase in order to suppress tumor cell growth and metastasis.
Ohio State University researchers have discovered novel subset of human CD34 (+) hematopoietic precursor cells and generated a method of isolating them.
An online interactive tool that helps a patients and physicians assess a likelihood of cancer or heart disease, based on family history.
A molecular tool for predicting risk of local and regional recurrence of pancreatic adenocarcinoma.
Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments.
Verbal communication of color is challenging, therefore mathematically-standardized color spaces are used. ColorBySpectra is software that in one click can convert large sets of absorbance data obtained from a simple spectrophotometer into color spaces: Hunter Lab, CIEL*c*h* and CIEL*a*b*. It reduces time for data collection, and sample volume and equipment needs. The software is useable on multiple platforms and would be useful in food science or other industries interested in precise color information.
The most abundant neurotransmitter in the central nervous system is glutamate. The role of this neurotransmitter is to send excitiatory signals to aid in modulation of normal brain function. However, abnormal release of glutamate can overstimulate the neuronal system, resulting in excitoxicty. Glutamate-mediated excitoxicity is involved in many neurological disorders, such as epilepsy, stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). Currently available drugs for the prevention of excitoxicity are not very effective and can produce detrimental side effects. The interplay between glutamate release and clearance is controlled, in large part, by the glial glutamate transporter, EAAT2. Thus, drugs that are able to control the activation of EAAT2 provide a novel and promising direction for development of therapeutics for neurodegenerative diseases.
Ohio State University researchers, led by Dr. Chien-Liang Lin and in partnership with Brigham and Women's Hospital, have developed an approach for preventing glutamate-mediated excitotoxicity. This technology is a series of novel small molecules that enhance the glutamate uptake function through expression of an excitatory amino acid transporters, EAAT2, which causes the glutamate to be removed from the synaptic cleft. The way of enhancing the EAAT2 expression is through translational activation. These drugs provide a novel alternative to traditional therupedics and hold promise for treatment of neurological diseases such as ALS.
Enhances glutamate uptake function which allows glutamate to be removed from synaptic cleft
Therapeutic effect in several animal models of diseases including ALS, epilepsy, Alzheimer's disease, and focal cerebral ischemia
A natural plant product possessing potent immunomodulatory activity, which primes T cell immune responses, and could be used for vaccine development.
Autophagy is impaired in patients with Cystic Fibrosis, rendering them susceptible to microbial infections. Autophagy is negatively regulated by microRNAs, Mir17 and Mir20, and this anti-microRNA antagomir may be optimized as a novel therapeutic to treat Cystic Fibrosis patients.
Stable, predictably ordered RNA nanopores for disease diagnosis and biopolymer sequencing.