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The SMN2 gene contains sequences that regulate the level of inclusion of SMN exon7 in SMN mRNA, and some of these act in a negative manner. Antisense oligonucleotides to block the negative regulating protein binding to these sites can increase inclusion of SMN exon 7 and thus, the amount of SMN being produced.
A treatment for spinal muscular atrophy.
A novel plasmid addiction system for cost-effective end-product generation.
A novel method using the overexpression of survival motor neuron protein to improve motor unity synaptic repair and restore/protect muscle size and function due to sarcopenia.
Inh2-B1 serves as a therapeutically important “antibiotic-resistance-breaker,” which enhances the bactericidal activity of Ceftriaxone/Cefotaxime against highly pathogenic MDRSA infection.
A combination-therapy that has the potential to overcome and/or prevent the commonly observed acquisition of sorafenib resistance, which is associated with treatment failure in patients with hepatocellular carcinoma.
A method of evenly distributing beneficial mites throughout a greenhouse using a novel device.
A specific and rapidly reversible system for single molecule capture employing magnesium-dependent DNA quadruplex structures.
An enhanced nucleic acid amplification system that is more efficient and cost-effective than conventional polymerase chain reaction methods.
An efficient delivery vehicle for therapeutic oligonucleotides with high efficiency.