Summary:

Stabilized peptide structures can be used to bind to target molecules, such as proteins, to influence biological activity. Researchers at Ohio State University have developed a method by which a stabilzed peptide secondary structure and tertiary contacts can be sythesized simutaneously. The addition of a tertiary contact is not possible using the current methods. The current methods use a intramolecular ring closing methathesis (RCM), while this method uses a intermolecular RCM, allowing for greater control.

Potential Applications:

• Novel therapuetic synthesis
• New material sythesises using chemical reactions, such as polymerization depending on functional group added

Advantages:

• Ability to control functionality with tertiary contact
• Confer functionality and structure in one reaction