Summary:

A novel regenerative strategy for tissue repair has been developed that reduces and/or eliminates the drawbacks associated with current treatments for injured or inferior tissues. The use of xenogeneic cell sources in these regenerative strategies is one approach. The strategy also provides a transplant system including a cell adapted for transplant from a xenogeneic donor to a host, wherein the cell is engineered to express pdl1. Regenerative strategies for bone and cartilage repair offer significant impact by reducing morbidity of musculoskeletal diseases and their burden on the socioeconomic system, as well as reducing costs for reimbursements by the present health care system.

Potential Applications:

• Companies that provide therapies for patients with musculoskeletal afflictions

Advantages:

• Highly effective therapy at lower cost.
• Reduces cost of patient hospitalization, dependent living, lost work and morbidity that limit quality of life.
• Does not trigger immune response in the host.